Ontology highlight
ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC5314791 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhou Rui R Park Juw Won JW Chun Rene F RF Lisse Thomas S TS Garcia Alejandro J AJ Zavala Kathryn K Sea Jessica L JL Lu Zhi-Xiang ZX Xu Jianzhong J Adams John S JS Xing Yi Y Hewison Martin M
Nucleic acids research 20160926 2
Traditionally recognized as an RNA splicing regulator, heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNPC1/C2) can also bind to double-stranded DNA and function in trans as a vitamin D response element (VDRE)-binding protein. As such, hnRNPC1/C2 may couple transcription induced by the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D) with subsequent RNA splicing. In MG63 osteoblastic cells, increased expression of the 1,25(OH)<sub>2</sub>D target gene CYP24A1 involved ...[more]