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ABSTRACT:
SUBMITTER: Silva-Brenes D
PROVIDER: S-EPMC5315060 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Silva-Brenes Diana D Delgado Loruhama L Rivera José M JM
Organic & biomolecular chemistry 20170101 4
We report the synthesis and self-assembly of two lipophilic 2'-deoxyguanosine (G) derivatives whose fluorescence intensity is modulated by self-assembly into supramolecular G-quadruplexes (SGQs). Whereas both derivatives self-assemble isostructurally, one shows up to 100% emission enhancement while the other shows an initial enhancement, followed by 10% quenching. Thus, the rotational restrictions resulting from self-assembly are enough to induce significant changes in emission, but it is critic ...[more]