Ontology highlight
ABSTRACT:
SUBMITTER: McCown PJ
PROVIDER: S-EPMC5315370 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
McCown Phillip J PJ Winkler Wade C WC Breaker Ronald R RR
Methods in molecular biology (Clifton, N.J.) 20120101
Among the nine classes of ribozymes that have been experimentally validated to date is the metabolite-responsive self-cleaving ribozyme called glmS. This RNA is almost exclusively located in the 5'-untranslated region of bacterial mRNAs that code for the production of GlmS proteins, which catalyze the synthesis of the aminosugar glucosamine-6-phosphate (GlcN6P). Each glmS ribozyme forms a conserved catalytic core that selectively binds GlcN6P and uses this metabolite as a cofactor to promote rib ...[more]