Ontology highlight
ABSTRACT:
SUBMITTER: Ponzoni L
PROVIDER: S-EPMC5315405 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
PLoS computational biology 20170203 2
G protein-coupled receptors (GPCRs) are the largest superfamily of signaling proteins. Their activation process is accompanied by conformational changes that have not yet been fully uncovered. Here, we carry out a novel comparative analysis of internal structural fluctuations across a variety of receptors from class A GPCRs, which currently has the richest structural coverage. We infer the local mechanical couplings underpinning the receptors' functional dynamics and finally identify those amino ...[more]