Ontology highlight
ABSTRACT:
SUBMITTER: Niu B
PROVIDER: S-EPMC5315576 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Niu Beifang B Scott Adam D AD Sengupta Sohini S Bailey Matthew H MH Batra Prag P Ning Jie J Wyczalkowski Matthew A MA Liang Wen-Wei WW Zhang Qunyuan Q McLellan Michael D MD Sun Sam Q SQ Tripathi Piyush P Lou Carolyn C Ye Kai K Mashl R Jay RJ Wallis John J Wendl Michael C MC Chen Feng F Ding Li L
Nature genetics 20160613 8
Local concentrations of mutations are well known in human cancers. However, their three-dimensional spatial relationships in the encoded protein have yet to be systematically explored. We developed a computational tool, HotSpot3D, to identify such spatial hotspots (clusters) and to interpret the potential function of variants within them. We applied HotSpot3D to >4,400 TCGA tumors across 19 cancer types, discovering >6,000 intra- and intermolecular clusters, some of which showed tumor and/or tis ...[more]