Ontology highlight
ABSTRACT:
SUBMITTER: Cheng AC
PROVIDER: S-EPMC5954141 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cheng Alan C AC Doherty Elizabeth M EM Johnstone Sheree S DiMauro Erin F EF Dao Jennifer J Luthra Abhinav A Ye Jay J Tang Jie J Nixey Thomas T Min Xiaoshan X Tagari Philip P Miranda Les P LP Wang Zhulun Z
Scientific reports 20180515 1
Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of "chemibodies" as small molecule-antibody hybrids that offer dual recognition of a single target by both a small molecule and an antibody, using DPP-IV enzyme as a proof of concept study. Biochemical characterization demonstrates that the chemibodies present superior DPP-IV inhibition compared to either small molecule or antibody ...[more]