Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC5316423 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nanoscale 20170101 4
Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time visualization. TT3-Gd18 LLNs were identified as a lead formulation, which was able to encapsulate 91% of mRNA and 74% of Gd. This formulation showed a comparab ...[more]