Ontology highlight
ABSTRACT:
SUBMITTER: Fujii K
PROVIDER: S-EPMC5316868 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Fujii Kotaro K Shi Zhen Z Zhulyn Olena O Denans Nicolas N Barna Maria M
Nature communications 20170214
The degree and dynamics of translational control during mammalian development remain poorly understood. Here we monitored translation of the mammalian genome as cells become specified and organize into tissues in vivo. This identified unexpected and pervasive translational regulation of most of the core signalling circuitry including Shh, Wnt, Hippo, PI3K and MAPK pathways. We further identify and functionally characterize a complex landscape of upstream open reading frames (uORFs) across 5'-unt ...[more]