Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues DC
PROVIDER: S-EPMC7181744 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Rodrigues Deivid Carvalho DC Harvey Emily M EM Suraj Rejitha R Erickson Sarah L SL Mohammad Lamees L Ren Mengli M Liu Hongrui H He Guiqiong G Kaplan David R DR Ellis James J Yang Guang G
Nature communications 20200424 1
Gene regulation and metabolism are two fundamental processes that coordinate the self-renewal and differentiation of neural precursor cells (NPCs) in the developing mammalian brain. However, little is known about how metabolic signals instruct gene expression to control NPC homeostasis. Here, we show that methylglyoxal, a glycolytic intermediate metabolite, modulates Notch signalling to regulate NPC fate decision. We find that increased methylglyoxal suppresses the translation of Notch1 receptor ...[more]