Ontology highlight
ABSTRACT:
SUBMITTER: Rajendran E
PROVIDER: S-EPMC5316894 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Rajendran Esther E Hapuarachchi Sanduni V SV Miller Catherine M CM Fairweather Stephen J SJ Cai Yeping Y Smith Nicholas C NC Cockburn Ian A IA Bröer Stefan S Kirk Kiaran K van Dooren Giel G GG
Nature communications 20170216
Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Here we demonstrate that members of an apicomplexan-specific protein family-the Novel Putative Transporters (NPTs)-play key roles in the uptake of cationic amino acids. We show that an NPT from Toxoplasma gondii (TgNPT1) is a selective arginine tran ...[more]