Ontology highlight
ABSTRACT:
SUBMITTER: Ohtake M
PROVIDER: S-EPMC5316938 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Ohtake Makoto M Umemura Masanari M Sato Itaru I Akimoto Taisuke T Oda Kayoko K Nagasako Akane A Kim Jeong-Hwan JH Fujita Takayuki T Yokoyama Utako U Nakayama Tomohiro T Hoshino Yujiro Y Ishiba Mai M Tokura Susumu S Hara Masakazu M Muramoto Tomoya T Yamada Sotoshi S Masuda Takatsugu T Aoki Ichio I Takemura Yasushi Y Murata Hidetoshi H Eguchi Haruki H Kawahara Nobutaka N Ishikawa Yoshihiro Y
Scientific reports 20170220
We previously reported that μ-oxo N,N'-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell prolife ...[more]