Ontology highlight
ABSTRACT:
SUBMITTER: Laing EE
PROVIDER: S-EPMC5318160 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Laing Emma E EE Möller-Levet Carla S CS Poh Norman N Santhi Nayantara N Archer Simon N SN Dijk Derk-Jan DJ
eLife 20170220
Diagnosis and treatment of circadian rhythm sleep-wake disorders both require assessment of circadian phase of the brain's circadian pacemaker. The gold-standard univariate method is based on collection of a 24-hr time series of plasma melatonin, a suprachiasmatic nucleus-driven pineal hormone. We developed and validated a multivariate whole-blood mRNA-based predictor of melatonin phase which requires few samples. Transcriptome data were collected under normal, sleep-deprivation and abnormal sle ...[more]