Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.
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ABSTRACT:
SUBMITTER: Corrada MM
PROVIDER: S-EPMC5318224 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study.
Corrada María M MM Hayden Kathleen M KM Paganini-Hill Annlia A Bullain Szofia S SS DeMoss Jaime J Aguirre Colette C Brookmeyer Ron R Kawas Claudia H CH
Alzheimer's & dementia : the journal of the Alzheimer's Association 20170117 2
<h4>Introduction</h4>We investigated the association between age of onset of hypertension and dementia risk in an oldest-old cohort.<h4>Methods</h4>Participants are from The 90+ Study, a population-based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self-reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were ...[more]
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Project description:Aging is known to have deleterious effects on cerebral white matter, yet little is known about these white matter alterations in advanced age. In this study, 94 oldest-old adults without dementia (90-103 years) underwent diffusion tensor imaging to assess relationships between chronological age and multiple measures of integrity in 18 white matter regions across the brain. Results revealed significant age-related declines in integrity in regions previously identified as being sensitive to aging in younger-old adults (corpus callosum, fornix, cingulum, external capsule). For the corpus callosum, the effect of age on genu fractional anisotropy was significantly weaker than the relationship between age and splenium fractional anisotropy. Importantly, age-related declines in white matter integrity did not differ in cognitively normal and cognitively impaired not demented oldest-old, suggesting that they were not solely driven by cognitive dysfunction or preclinical dementia in this advanced age group. Instead, white matter in these regions appears to remain vulnerable to normal aging processes through the 10th decade of life.
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