Dataset Information

Glucose level decline precedes dementia in elderly African Americans with diabetes.

ABSTRACT:

Introduction

High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients.

Methods

A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome variables.

Results

Diabetic participants who developed incident dementia had a significant decrease in serum glucose levels in the years preceding the diagnosis compared to the participants with normal cognition (P = .0002). They also had significantly higher glucose levels up to 9 years before the dementia diagnosis (P = .0367).

Discussion

High glucose levels followed by a decline occurring years before diagnosis in African American participants with diabetes may represent a powerful presymptomatic metabolic indicator of dementia.

SUBMITTER: Hendrie HC

PROVIDER: S-EPMC5318260 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Publications

Glucose level decline precedes dementia in elderly African Americans with diabetes.

Hendrie Hugh C HC Zheng Mengjie M Li Wei W Lane Kathleen K Ambuehl Roberta R Purnell Christianna C Unverzagt Frederick W FW Torke Alexia A Balasubramanyam Ashok A Callahan Chris M CM Gao Sujuan S

Alzheimer's & dementia : the journal of the Alzheimer's Association 20161025 2

<h4>Introduction</h4>High blood glucose levels may be responsible for the increased risk for dementia in diabetic patients.<h4>Methods</h4>A secondary data analysis merging electronic medical records (EMRs) with data collected from the Indianapolis-Ibadan Dementia project (IIDP). Of the enrolled 4105 African Americans, 3778 were identified in the EMR. Study endpoints were dementia, mild cognitive impairment (MCI), or normal cognition. Repeated serum glucose measurements were used as the outcome ...[more]

PMID: 27793691

Similar Datasets

Project description:ObjectiveThis study was undertaken to evaluate the frequency of modifiable dementia risk factors and their association with cognitive impairment and rate of decline in diverse participants engaged in studies of memory and aging.MethodsModifiable dementia risk factors and their associations with cognitive impairment and cognitive decline were determined in community-dwelling African American (AA; n = 261) and non-Hispanic White (nHW; n = 193) participants who completed ≥2 visits at the Mayo Clinic Alzheimer Disease Research Center in Jacksonville, Florida. Risk factors and their associations with cognitive impairment (global Clinical Dementia Rating [CDR] ≥ 0.5) and rates of decline (CDR Sum of Boxes) in impaired participants were compared in AA and nHW participants, controlling for demographics, APOE ɛ4 status, and Area Deprivation Index.ResultsHypertension, hypercholesterolemia, obesity, and diabetes were overrepresented in AA participants, but were not associated with cognitive impairment. Depression was associated with increased odds of cognitive impairment in AA (odds ratio [OR] = 4.30, 95% confidence interval [CI] = 2.13-8.67) and nHW participants (OR = 2.79, 95% CI = 1.21-6.44) but uniquely associated with faster decline in AA participants (β = 1.71, 95% CI = 0.69-2.73, p = 0.001). Fewer AA participants reported antidepressant use (9/49, 18%) than nHW counterparts (57/78, 73%, p < 0.001). Vitamin B12 deficiency was also associated with an increased rate of cognitive decline in AA participants (β = 2.65, 95% CI = 0.38-4.91, p = 0.023).InterpretationModifiable dementia risk factors are common in AA and nHW participants, representing important risk mitigation targets. Depression was associated with dementia in AA and nHW participants, and with accelerated declines in cognitive function in AA participants. Optimizing depression screening and treatment may improve cognitive trajectories and outcomes in AA participants. ANN NEUROL 2024;95:518-529.

Dataset Information

Glucose level decline precedes dementia in elderly African Americans with diabetes.

Introduction

Methods

Results

Discussion

Publications

Glucose level decline precedes dementia in elderly African Americans with diabetes.

Similar Datasets

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