Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout.
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ABSTRACT:
SUBMITTER: Shao T
PROVIDER: S-EPMC5318445 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout.
Shao Tiejuan T Shao Li L Li Haichang H Xie Zhijun Z He Zhixing Z Wen Chengping C
Frontiers in microbiology 20170221
This study employed microbiome and metabolome analysis to explore the fecal signatures of gout patients. Fecal samples from 52 male individuals (26 healthy controls and 26 gout patients) were analyzed by <sup>1</sup>H NMR spectroscopy and Illumina Miseq sequencing. The signatures of microbiome showed being up-regulation of opportunistic pathogens, such as <i>Bacteroides, Porphyromonadaceae Rhodococcus</i>, <i>Erysipelatoclostridium</i> and <i>Anaerolineaceae</i>. The signatures of metabolome wer ...[more]
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