Ontology highlight
ABSTRACT:
SUBMITTER: Harjes U
PROVIDER: S-EPMC5318662 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Harjes U U Bridges E E Gharpure K M KM Roxanis I I Sheldon H H Miranda F F Mangala L S LS Pradeep S S Lopez-Berestein G G Ahmed A A Fielding B B Sood A K AK Harris A L AL
Oncogene 20160829 7
Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Previously we have shown that FABP4 in endothelial cells is induced by the NOTCH1 signalling pathway, the latter of which is involved in mechanisms of resistance to antiangiogenic tumour therapy. Here, we investigated the role of FABP4 in endothelial fatty acid metabolism and tumour angiogenesis. We analysed the effect of transient FABP4 knockdown in human umbilical vein endothelial ...[more]