Ontology highlight
ABSTRACT:
SUBMITTER: Ordonez P
PROVIDER: S-EPMC5318888 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20170221
SAMHD1 is an intracellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside and inorganic triphosphate. In myeloid-derived dendritic cells and macrophages as well as resting T-cells, SAMHD1 blocks HIV-1 infection through this dNTP triphosphohydrolase activity by reducing the cellular dNTP pool to a level that cannot support productive reverse transcription. We now show that, in addition to this direct effect on virus replication, manipulating cellular SAM ...[more]