Ontology highlight
ABSTRACT:
SUBMITTER: Davenne T
PROVIDER: S-EPMC7225753 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Cell reports 20200501 6
The anti-leukemia agent forodesine causes cytotoxic overload of intracellular deoxyguanosine triphosphate (dGTP) but is efficacious only in a subset of patients. We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphosphate (dNTP), protects cells against the effects of dNTP imbalances. SAMHD1-deficient cells induce intrinsic apoptosis upon provision of deoxyribonucleosides, particularly deoxyguanosine (dG). Moreover, dG and forodesine act synergistically to kill cells lack ...[more]