Elevated FABP1 serum levels are associated with poorer survival in acetaminophen-induced acute liver failure.

ABSTRACT: Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Serum liver-type fatty acid binding protein (FABP1) early (day 1) or late (day 3-5) levels are associated with 21-day mortality in the absence of liver transplant. Serum samples from 198 APAP-ALF patients (nested case-control study with 99 survivors, 99 nonsurvivors) were analyzed by enzyme-linked immunosorbent assay with clinical data from the US Acute Liver Failure Study Group registry (1998-2014). APAP-ALF survivors had significantly lower serum FABP1 levels early (238.6 versus 690.8?ng/mL, P??350?ng/mL was associated with significantly higher risk of death at early (P?=?0.0004) and late (P?

SUBMITTER: Karvellas CJ 

PROVIDER: S-EPMC5319885 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature