Ontology highlight
ABSTRACT:
SUBMITTER: Zhao GJ
PROVIDER: S-EPMC5320320 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Zhao Guang-Ju GJ Zheng Jia-Yi JY Bian Jia-Lan JL Chen Long-Wang LW Dong Ning N Yu Yan Y Hong Guang-Liang GL Chandoo Arvine A Yao Yong-Ming YM Lu Zhong-Qiu ZQ
Mediators of inflammation 20170208
<i>Background.</i> Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study was designed to investigate whether Tregs express TAM receptors and the potential role of Gas6-TAM signal in regulating the suppressive function of Tregs. ...[more]