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Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne.

ABSTRACT: Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.0^2,8.0^3,7] tetradecane ring system, and the probable biogenetic precursor [3, (1R*,2E,4R*,7E,10S*,11S*,12R*)-10, 18-diacetoxydolabella-2,7-dien-6-one] of 1?2 were isolated from the South China Sea marine sponge Hippospongia lachne. The structures of the novel compounds were determined using integrated spectroscopic methods in combination with single-crystal X-ray diffraction analysis. Compounds 1?2 showed potent inhibitory activity on the release of ?-hexosaminidase, a biomarker for degranulation, as well as the production of pro-inflammatory cytokine IL-4 and lipid mediator LTB₄ in DNP-IgE-stimulated RBL-2H3 cells.

SUBMITTER: Hong LL

PROVIDER: S-EPMC5320514 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne.

Hong Li-Li LL Yu Hao-Bing HB Wang Jie J Jiao Wei-Hua WH Cheng Bao-Hui BH Yang Fan F Zhou Yong-Jun YJ Gu Bin-Bin BB Song Shao-Jiang SJ Lin Hou-Wen HW

Scientific reports 20170222

Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.02,8.03,7] tetradecane ring system, and the probable biogenetic precursor [3, (1R*,2E,4R*,7E,10S*,11S*,12R*)-10, 18-diacetoxydolabella-2,7-dien-6-one] of 1‒2 were isolated from the South China Sea marine sponge Hippospongia lachne. The structures of the novel compounds were determined using integrated spectroscopic methods in combination with single-crystal X-ray diffraction analysis. Compounds ...[more]

PMID: 28224981

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