Ontology highlight
ABSTRACT:
SUBMITTER: Shin JH
PROVIDER: S-EPMC5320713 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Cell & bioscience 20170222
As a key enzyme for gene expression, RNA polymerase II (pol II) reads along the DNA template and catalyzes accurate mRNA synthesis during transcription. On the other hand, genomic DNA is under constant attack by endogenous and environmental stresses. These attack cause many DNA lesions. Pol II functions as a specific sensor that is able to recognize changes in DNA sequences and structures and induces different outcomes. A critical question in the field is how Pol II recognizes and senses these D ...[more]