Ontology highlight
ABSTRACT:
SUBMITTER: Sundaramoorthy E
PROVIDER: S-EPMC5321136 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Sundaramoorthy Elayanambi E Leonard Marilyn M Mak Raymond R Liao Jeffrey J Fulzele Amitkumar A Bennett Eric J EJ
Molecular cell 20170126 4
Ribosomes that experience terminal stalls during translation are resolved by ribosome-associated quality control (QC) pathways that oversee mRNA and nascent chain destruction and recycle ribosomal subunits. The proximal factors that sense stalled ribosomes and initiate mammalian ribosome-associated QC events remain undefined. We demonstrate that the ZNF598 ubiquitin ligase and the 40S ribosomal protein RACK1 help to resolve poly(A)-induced stalled ribosomes. They accomplish this by regulating di ...[more]