Ontology highlight
ABSTRACT:
SUBMITTER: Galdeano C
PROVIDER: S-EPMC5321501 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Galdeano Carles C Ciulli Alessio A
Future medicinal chemistry 20160519 13
Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug discovery. Recent years have seen an explosion of interest in developing small molecules binding to bromodomains, the readers of acetyl-lysine modifications. A plethora of co-crystal structures has motivated focused fragment-based design and optimization programs within both industry and academia. These efforts have yielded several compounds entering the clinic, and many more are increasingly being used as c ...[more]