Ontology highlight
ABSTRACT:
SUBMITTER: Baud MGJ
PROVIDER: S-EPMC4458378 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20141016 6209
Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra-Terminal (BET) proteins have attracted interest because of their roles in transcriptional regulation, epigenetics, and cancer. The BET bromodomains (protein interaction modules that bind acetyl-lysine) have been targeted by potent small-molecule inh ...[more]