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Exploring Correlates of Alcohol-Specific Social Reactions in Alcohol-Involved Sexual Assaults.

ABSTRACT: Disclosing pre-assault drinking may influence reactions sexual assault survivors receive from their support networks. Such reactions likely affect survivor's post-assault adjustment. Thus, it is important to identify assault and disclosure characteristics related to disclosing one's drinking and receiving social reactions that specifically comment on pre-assault alcohol use. This exploratory study examined demographic, assault, and disclosure factors as predictors of both survivors' decisions to disclose their pre-assault alcohol use and social reactions survivors received related to their pre-assault alcohol use. Out of survivors who were drinking at the time of the assault, those with more education and who reported greater alcohol impairment or resistance during the assault were more likely to disclose pre-assault alcohol use. As expected, this study found that of women disclosing pre-assault drinking, those with more education and more violent assaults received more negative social reactions specifically commenting on their use of alcohol prior to the assault. Such negative reactions were more common for those telling parents, police, or medical professionals. Women with less education received more positive and negative social reactions that commented specifically on their use of alcohol prior to the assault. Interestingly, results showed that disclosing pre-assault alcohol use in greater detail was related to positive social reactions specific to preassault drinking and experiencing greater alcohol impairment at the time of the assault was associated with both positive and negative social reactions specific to pre-assault alcohol use. Implications for research and intervention are provided for survivors disclosing alcohol-related sexual assaults.

SUBMITTER: Lorenz K

PROVIDER: S-EPMC5321657 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Exploring Correlates of Alcohol-Specific Social Reactions in Alcohol-Involved Sexual Assaults.

Lorenz Katherine K Ullman Sarah E SE

Journal of aggression, maltreatment & trauma 20160913 10

Disclosing pre-assault drinking may influence reactions sexual assault survivors receive from their support networks. Such reactions likely affect survivor's post-assault adjustment. Thus, it is important to identify assault and disclosure characteristics related to disclosing one's drinking and receiving social reactions that specifically comment on pre-assault alcohol use. This exploratory study examined demographic, assault, and disclosure factors as predictors of both survivors' decisions to ...[more]

PMID: 28239252

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Project description:Background and objectivesRemimazolam is a new ultra-short-acting benzodiazepine currently being developed for intravenous use in procedural sedation, general anaesthesia, and intensive care unit sedation. Benzodiazepines represent a drug class associated with drug-facilitated sexual assaults, especially in combination with alcohol. Two clinical trials were designed to evaluate the oral bioavailability and pharmacokinetics/pharmacodynamics of remimazolam and to assess the potential for remimazolam misuse in drug-facilitated sexual assaults via oral ingestion.MethodsTrial 1 was conducted in 14 healthy volunteers to evaluate the oral bioavailability of remimazolam. Part 1 of trial 2 was conducted in 21 healthy female volunteers to find the minimal biologically active dose of oral remimazolam. Part 2 of trial 2 was conducted in 11 healthy female volunteers to evaluate the pharmacokinetics/pharmacodynamics of oral remimazolam in combination with alcohol.ResultsRemimazolam undergoes rapid and extensive first-pass metabolism upon oral administration. The oral bioavailability of remimazolam was negligible (2.2% based on total systemic exposure and 1.2% based on maximum plasma concentration). Plasma clearance of both remimazolam and its metabolite was fast (elimination half-life 20‒40 min and 1.75‒2 h, respectively). Alcohol did not appear to inhibit the rapid first-pass metabolism of remimazolam. No clear sedative effects were observed for remimazolam without alcohol. Significant sedation was observed in one of ten subjects after remimazolam 360 mg (18 drug product vials) + 40% v/v alcohol.ConclusionThe oral bioavailability of remimazolam is negligible, which-together with its distinct bitter taste-suggests no meaningful potential for misuse in drug-facilitated sexual assaults via oral ingestion, with or without alcohol.Clinical trial registration numbersTrial 1 (NCT04113564) and trial 2 (NCT04113343) both retrospectively registered on 2 October 2019.

Project description:ObjectiveThe authors examined psychiatric comorbidities associated with alcohol use disorders and tobacco use disorders among heterosexual, bisexual, and gay and lesbian men and women in the United States and whether stress-related factors were predictive of comorbidities.MethodsThe authors used data from the National Epidemiologic Survey on Alcohol and Related Conditions-III (2012-2013, N=36,309) to examine the co-occurrence of past-year alcohol or tobacco use disorder with past-year anxiety disorders, mood disorders, and posttraumatic stress disorder by sexual identity (heterosexual, bisexual, gay or lesbian) and sex. The authors also examined the association of stress-related factors and social support with the presence of comorbidities.ResultsComorbidities were more prevalent among women and sexual minorities, particularly bisexual women. More than half of bisexual (55%) and gay or lesbian (51%) individuals who met criteria for a past-year alcohol use disorder had a psychiatric comorbidity, while only one-third of heterosexual individuals who met criteria for a past-year alcohol use disorder did. Similar differences were found among those who met criteria for a past-year tobacco use disorder. Among sexual minorities, the frequency of sexual orientation discrimination (adjusted odds ratio range=1.08-1.10), number of stressful life events (adjusted odds ratio range=1.25-1.43), and number of adverse childhood experiences (adjusted odds ratio range=1.04-1.18) were significantly associated with greater odds of comorbidities. Greater social support was significantly inversely associated with tobacco use disorder comorbidities (adjusted odds ratio range=0.96-0.97).ConclusionsThis research suggests that integrated substance use and mental health prevention and treatment programs are needed, particularly for individuals who identify as sexual minorities. The increased stressors experienced by sexual minority individuals may be important drivers of these high levels of comorbidities.

Dataset Information

Exploring Correlates of Alcohol-Specific Social Reactions in Alcohol-Involved Sexual Assaults.

Publications

Exploring Correlates of Alcohol-Specific Social Reactions in Alcohol-Involved Sexual Assaults.

Similar Datasets

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