?2-adrenergic receptor control of endosomal PTH receptor signaling via G??.
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ABSTRACT:
SUBMITTER: Jean-Alphonse FG
PROVIDER: S-EPMC5322277 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
β<sub>2</sub>-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.
Jean-Alphonse Frédéric G FG Wehbi Vanessa L VL Chen Jingming J Noda Masaki M Taboas Juan M JM Xiao Kunhong K Vilardaga Jean-Pierre JP
Nature chemical biology 20161226 3
Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the β<sub>2</sub>-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid ...[more]
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