Ontology highlight
ABSTRACT:
SUBMITTER: Mahon BP
PROVIDER: S-EPMC5322481 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Biochemistry 20160805 33
Human carbonic anhydrase IX (hCA IX) expression in many cancers is associated with hypoxic tumors and poor patient outcome. Inhibitors of hCA IX have been used as anticancer agents with some entering Phase I clinical trials. hCA IX is transmembrane protein whose catalytic domain faces the extracellular tumor milieu, which is typically associated with an acidic microenvironment. Here, we show that the catalytic domain of hCA IX (hCA IX-c) exhibits the necessary biochemical and biophysical propert ...[more]