Ontology highlight
ABSTRACT:
SUBMITTER: Alterio V
PROVIDER: S-EPMC2752527 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Alterio Vincenzo V Hilvo Mika M Di Fiore Anna A Supuran Claudiu T CT Pan Peiwen P Parkkila Seppo S Scaloni Andrea A Pastorek Jaromir J Pastorekova Silvia S Pedone Carlo C Scozzafava Andrea A Monti Simona Maria SM De Simone Giuseppina G
Proceedings of the National Academy of Sciences of the United States of America 20090914 38
Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the alpha-CA enzyme family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a prognostic factor in several human cancers. An aberrant increase in CA IX expression in chronic hypoxia and during development of various carcinomas contributes to tumorigenesis through at least two mechanisms: pH regulation and cell adhesion control. Here we report the X-ray structure of the catalytic domain of CA ...[more]