Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.
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ABSTRACT:
SUBMITTER: Dorfman MD
PROVIDER: S-EPMC5322503 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice.
Dorfman Mauricio D MD Krull Jordan E JE Douglass John D JD Fasnacht Rachael R Lara-Lince Fernando F Meek Thomas H TH Shi Xiaogang X Damian Vincent V Nguyen Hong T HT Matsen Miles E ME Morton Gregory J GJ Thaler Joshua P JP
Nature communications 20170222
Female mice are less susceptible to the negative metabolic consequences of high-fat diet feeding than male mice, for reasons that are incompletely understood. Here we identify sex-specific differences in hypothalamic microglial activation via the CX3CL1-CX3CR1 pathway that mediate the resistance of female mice to diet-induced obesity. Female mice fed a high-fat diet maintain CX3CL1-CX3CR1 levels while male mice show reductions in both ligand and receptor expression. Female Cx3cr1 knockout mice d ...[more]
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