Ontology highlight
ABSTRACT:
SUBMITTER: Zinder JC
PROVIDER: S-EPMC5322736 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zinder John C JC Lima Christopher D CD
Genes & development 20170101 2
The eukaryotic RNA exosome is an essential and conserved protein complex that can degrade or process RNA substrates in the 3'-to-5' direction. Since its discovery nearly two decades ago, studies have focused on determining how the exosome, along with associated cofactors, achieves the demanding task of targeting particular RNAs for degradation and/or processing in both the nucleus and cytoplasm. In this review, we highlight recent advances that have illuminated roles for the RNA exosome and its ...[more]