Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance.

ABSTRACT:

Objective

Triggering receptor expressed on myeloid cells (TREM)-1 has recently been recognized as one of the potent amplifiers of acute and chronic inflammation. However, the exact role of TREM-1 in regard to insulin insensitivity is unknown.

Methods

mRNA transcripts and protein expression of TREM-1, TREM-2, and TREM-1/TREM-2 ratio were examined in the tissue biopsies (liver, omentum, and subcutaneous fat) and blood samples (neutrophils and monocytes) of subjects with obesity and diabetes (SO⁺ D⁺ ; n = 15), subjects with obesity but not diabetes (SO⁺ D^- ; n = 7), and subjects without obesity (BMI < 30) and diabetes (SO^- D^- ; n = 5).

Results

The immunofluorescence and RT-PCR revealed significant increase

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC5323323 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature