Ontology highlight
ABSTRACT:
SUBMITTER: Kamihara Y
PROVIDER: S-EPMC5325446 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kamihara Yusuke Y Takada Kohichi K Sato Tsutomu T Kawano Yutaka Y Murase Kazuyuki K Arihara Yohei Y Kikuchi Shohei S Hayasaka Naotaka N Usami Makoto M Iyama Satoshi S Miyanishi Koji K Sato Yasushi Y Kobune Masayoshi M Kato Junji J
Oncotarget 20160901 39
Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression of ferroportin, which is the only identified non-heme iron exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, the altered iron metabolism in MM biology remains unclear. In this study we demonstrated, by live cell imaging, that MM cells have increased intracellular iron levels as compared with normal cells. In experiments to test the effe ...[more]