Ontology highlight
ABSTRACT:
SUBMITTER: Gottwald EM
PROVIDER: S-EPMC6994599 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Gottwald Esther M EM Schuh Claus D CD Drücker Patrick P Haenni Dominik D Pearson Adam A Ghazi Susan S Bugarski Milica M Polesel Marcello M Duss Michael M Landau Ehud M EM Kaech Andres A Ziegler Urs U Lundby Anne K M AKM Lundby Carsten C Dittrich Petra S PS Hall Andrew M AM
Scientific reports 20200131 1
The iron chelator Deferasirox (DFX) causes severe toxicity in patients for reasons that were previously unexplained. Here, using the kidney as a clinically relevant in vivo model for toxicity together with a broad range of experimental techniques, including live cell imaging and in vitro biophysical models, we show that DFX causes partial uncoupling and dramatic swelling of mitochondria, but without depolarization or opening of the mitochondrial permeability transition pore. This effect is expla ...[more]