Ontology highlight
ABSTRACT:
SUBMITTER: Zeng S
PROVIDER: S-EPMC5326618 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zeng Shengyuan S Wang Yangyang Y Zhang Ting T Bai Lu L Wang Yalan Y Duan Changzhu C
Protein & cell 20161014 3
UHRF2 is a ubiquitin-protein ligase E3 that regulates cell cycle, genomic stability and epigenetics. We conducted a co-immunoprecipitation assay and found that TIP60 and HDAC1 interact with UHRF2. We previously demonstrated that UHRF2 regulated H3K9ac and H3K14ac differentially in normal and cancer cells. However, the accurate signal transduction mechanisms were not clear. In this study, we found that TIP60 acted downstream of UHRF2 to regulate H3K9ac and H3K14ac expression. TIP60 is stabilized ...[more]