Effect of Atomoxetine Treatment on Reading and Phonological Skills in Children with Dyslexia or Attention-Deficit/Hyperactivity Disorder and Comorbid Dyslexia in a Randomized, Placebo-Controlled Trial.

ABSTRACT: OBJECTIVES:Evaluated the effects of atomoxetine on the reading abilities of children with dyslexia only or attention-deficit/hyperactivity disorder (ADHD) and comorbid dyslexia. METHODS:Children aged 10-16 years (N?=?209) met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) criteria for dyslexia only (n?=?58), ADHD and comorbid dyslexia (n?=?124), or ADHD only (n?=?27) and were of normal intelligence. Patients were treated with atomoxetine (1.0-1.4?mg/kg/day) or placebo in a 16-week, randomized, placebo-controlled, double-blind trial. The dyslexia-only and ADHD and comorbid dyslexia groups were randomized 1:1; the ADHD-only group received atomoxetine in a blinded manner. Reading abilities were measured with the Woodcock Johnson III (WJIII), Comprehensive Test of Phonological Processing (CTOPP), Gray Oral Reading Tests-4, and Test of Word Reading Efficiency. RESULTS:Atomoxetine-treated dyslexia-only patients compared with placebo patients had significantly greater improvement (p?

SUBMITTER: Shaywitz S 

PROVIDER: S-EPMC5327054 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature