Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans.
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ABSTRACT:
SUBMITTER: Steubl D
PROVIDER: S-EPMC5327444 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans.
Steubl Dominik D Kumar Santhosh V SV Tato Maia M Mulay Shrikant R SR Larsson Anders A Lind Lars L Risérus Ulf U Renders Lutz L Heemann Uwe U Carlsson Axel C AC Ärnlöv Johan J Anders Hans-Joachim HJ
Scientific reports 20170227
Cardiovascular complications determine morbidity/mortality in chronic kidney disease (CKD). We hypothesized that progressive CKD drives the release of cathepsin-S (Cat-S), a cysteine protease that promotes endothelial dysfunction and cardiovascular complications. Therefore, Cat-S, soluble tumor-necrosis-factor receptor (sTNFR) 1/2 and glomerular filtration rate (GFR) were measured in a CKD mouse model, a German CKD-cohort (MCKD, n = 421) and two Swedish community-based cohorts (ULSAM, n = 764 an ...[more]
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