Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC5327928 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Xu Jian J Marshall John J JJ Fernandes Herman B HB Nomura Toshihiro T Copits Bryan A BA Procissi Daniele D Mori Susumu S Wang Lei L Zhu Yongling Y Swanson Geoffrey T GT Contractor Anis A
Cell reports 20170201 8
Kainate receptors are members of the glutamate receptor family that regulate synaptic function in the brain. They modulate synaptic transmission and the excitability of neurons; however, their contributions to neural circuits that underlie behavior are unclear. To understand the net impact of kainate receptor signaling, we generated knockout mice in which all five kainate receptor subunits were ablated (5ko). These mice displayed compulsive and perseverative behaviors, including over-grooming, a ...[more]