Ontology highlight
ABSTRACT:
SUBMITTER: Plotkin JL
PROVIDER: S-EPMC4131293 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Plotkin Joshua L JL Day Michelle M Peterson Jayms D JD Xie Zhong Z Kress Geraldine J GJ Rafalovich Igor I Kondapalli Jyothisri J Gertler Tracy S TS Flajolet Marc M Greengard Paul P Stavarache Mihaela M Kaplitt Michael G MG Rosinski Jim J Chan C Savio CS Surmeier D James DJ
Neuron 20140701 1
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed to striatal degeneration induced by the loss of cortically supplied brain-derived neurotrophic factor (BDNF). Here, we show that in mouse models of early symptomatic HD, BDNF delivery to the striatum and its activation of tyrosine-related kinase B (TrkB) receptors were normal. However, in striatal neurons responsible for movement suppressi ...[more]