Bidentate iminodiacetate modified dendrimer for bone imaging.
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ABSTRACT:
SUBMITTER: Pes L
PROVIDER: S-EPMC5328641 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Bidentate iminodiacetate modified dendrimer for bone imaging.
Pes Lara L Kim Young Y Tung Ching-Hsuan CH
Bioorganic & medicinal chemistry letters 20170120 5
A new dendrimer probe was designed for bone imaging. Bidentate iminodiacetate groups were introduced to the probe to obtain strong bind to bones. The assembled dendrimeric probe, with four iminodiacetate moieties and a fluorescent tag, displayed good selectivity to hydroxyapatite, calcium oxalate and calcium phosphate salts. In mice, the probe offered vivid skeletal details after intravenous delivery. ...[more]
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