Ontology highlight
ABSTRACT:
SUBMITTER: Kan W
PROVIDER: S-EPMC7200158 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kan Wei W Enos Michael D MD Korkmazhan Elgin E Muennich Stefan S Chen Dong-Hua DH Gammons Melissa V MV Vasishtha Mansi M Bienz Mariann M Dunn Alexander R AR Skiniotis Georgios G Weis William I WI
eLife 20200416
In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector Dishevelled (Dvl), leading to the recruitment of Axin and the inhibition of β-catenin phosphorylation. This process requires interaction of homologous DIX domains present in Dvl and Axin, but is mechanistically undefined. We show that Dvl DIX forms anti ...[more]