Ontology highlight
ABSTRACT:
SUBMITTER: Gnanadhas DP
PROVIDER: S-EPMC5330738 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Gnanadhas Divya Prakash DP Dash Prasanta K PK Sillman Brady B Bade Aditya N AN Lin Zhiyi Z Palandri Diana L DL Gautam Nagsen N Alnouti Yazen Y Gelbard Harris A HA McMillan JoEllyn J Mosley R Lee RL Edagwa Benson B Gendelman Howard E HE Gorantla Santhi S
The Journal of clinical investigation 20170130 3
Long-acting anti-HIV products can substantively change the standard of care for patients with HIV/AIDS. To this end, hydrophobic antiretroviral drugs (ARVs) were recently developed for parenteral administration at monthly or longer intervals. While shorter-acting hydrophilic drugs can be made into nanocarrier-encased prodrugs, the nanocarrier encasement must be boosted to establish long-acting ARV depots. The mixed-lineage kinase 3 (MLK-3) inhibitor URMC-099 provides this function by affecting a ...[more]