Ontology highlight
ABSTRACT:
SUBMITTER: Nowacek AS
PROVIDER: S-EPMC3401515 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Nowacek Ari S AS McMillan JoEllyn J Miller Reagan R Anderson Alec A Rabinow Barrett B Gendelman Howard E HE
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100317 4
We posit that improvements in pharmacokinetics and biodistributions of antiretroviral therapies (ART) for human immunodeficiency virus type one-infected people can be achieved through nanoformulationed drug delivery systems. To this end, we manufactured nanoparticles of atazanavir, efavirenz, and ritonavir (termed nanoART) and treated human monocyte-derived macrophages (MDM) in combination therapies to assess antiretroviral responses. This resulted in improved drug uptake, release, and antiretro ...[more]