Ontology highlight
ABSTRACT:
SUBMITTER: Schafer MJ
PROVIDER: S-EPMC5331226 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Schafer Marissa J MJ White Thomas A TA Iijima Koji K Haak Andrew J AJ Ligresti Giovanni G Atkinson Elizabeth J EJ Oberg Ann L AL Birch Jodie J Salmonowicz Hanna H Zhu Yi Y Mazula Daniel L DL Brooks Robert W RW Fuhrmann-Stroissnigg Heike H Pirtskhalava Tamar T Prakash Y S YS Tchkonia Tamara T Robbins Paul D PD Aubry Marie Christine MC Passos João F JF Kirkland James L JL Tschumperlin Daniel J DJ Kita Hirohito H LeBrasseur Nathan K NK
Nature communications 20170223
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasin ...[more]