Connecting genetic risk to disease end points through the human blood plasma proteome.
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ABSTRACT:
SUBMITTER: Suhre K
PROVIDER: S-EPMC5333359 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Connecting genetic risk to disease end points through the human blood plasma proteome.
Suhre Karsten K Arnold Matthias M Bhagwat Aditya Mukund AM Cotton Richard J RJ Engelke Rudolf R Raffler Johannes J Sarwath Hina H Thareja Gaurav G Wahl Annika A DeLisle Robert Kirk RK Gold Larry L Pezer Marija M Lauc Gordan G El-Din Selim Mohammed A MA Mook-Kanamori Dennis O DO Al-Dous Eman K EK Mohamoud Yasmin A YA Malek Joel J Strauch Konstantin K Grallert Harald H Peters Annette A Kastenmüller Gabi G Gieger Christian C Graumann Johannes J
Nature communications 20170227
Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease associations and translate them into clinical applications. However, although hundreds of genetic variants have been associated with complex disorders, the underlying molecular pathways often remain elusive. Associations with intermediate traits are key in establishing functional links between GWAS-identified risk-variants and disease end ...[more]
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