Ontology highlight
ABSTRACT:
SUBMITTER: Turner KM
PROVIDER: S-EPMC5334176 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Turner Kristen M KM Deshpande Viraj V Beyter Doruk D Koga Tomoyuki T Rusert Jessica J Lee Catherine C Li Bin B Arden Karen K Ren Bing B Nathanson David A DA Kornblum Harley I HI Taylor Michael D MD Kaushal Sharmeela S Cavenee Webster K WK Wechsler-Reya Robert R Furnari Frank B FB Vandenberg Scott R SR Rao P Nagesh PN Wahl Geoffrey M GM Bafna Vineet V Mischel Paul S PS
Nature 20170208 7643
Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood. We performed whole-genome sequencing, structural modelling and cytogenetic analyses of 17 different cancer types, including analysis of the structure and function of chromosomes during metaphase of 2,572 dividing cells, and developed a software package called ECdetec ...[more]