Ontology highlight
ABSTRACT:
SUBMITTER: Lv C
PROVIDER: S-EPMC5334794 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Lv Caixia C Stewart William J WJ Akanyeti Otar O Frederick Courtney C Zhu Jie J Santos-Sacchi Joseph J Sheets Lavinia L Liao James C JC Zenisek David D
Cell reports 20160609 12
Synaptic ribbons are structures made largely of the protein Ribeye that hold synaptic vesicles near release sites in non-spiking cells in some sensory systems. Here, we introduce frameshift mutations in the two zebrafish genes encoding for Ribeye and thus remove Ribeye protein from neuromast hair cells. Despite Ribeye depletion, vesicles collect around ribbon-like structures that lack electron density, which we term "ghost ribbons." Ghost ribbons are smaller in size but possess a similar number ...[more]