CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-? signaling.
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ABSTRACT:
SUBMITTER: Fang J
PROVIDER: S-EPMC5335555 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.
Fang Jia J Wei Yudong Y Lv Changrong C Peng Sha S Zhao Shanting S Hua Jinlian J
Scientific reports 20170303
Previous studies have shown that CD61 (integrin-β3) promotes the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into germ-like cells. However, the mechanism remains unclear. In this study, we showed that overexpression of CD61 in canine adipose-derived mesenchymal stem cells (cADMSCs) promotes their differentiation into primordial germ cell (PGC)-like cells. Quantitative real-time PCR, immunocytochemistry and western blot detected higher levels of PGC-specific markers ...[more]
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