Early mutation bursts in colorectal tumors.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC5336211 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Early mutation bursts in colorectal tumors.
Zhao Junsong J Salomon Matthew P MP Shibata Darryl D Curtis Christina C Siegmund Kimberly K Marjoram Paul P
PloS one 20170303 3
Tumor growth is an evolutionary process involving accumulation of mutations, copy number alterations, and cancer stem cell (CSC) division and differentiation. As direct observation of this process is impossible, inference regarding when mutations occur and how stem cells divide is difficult. However, this ancestral information is encoded within the tumor itself, in the form of intratumoral heterogeneity of the tumor cell genomes. Here we present a framework that allows simulation of these proces ...[more]
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