Ontology highlight
ABSTRACT:
SUBMITTER: Przybyla L
PROVIDER: S-EPMC5336327 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Przybyla Laralynne L Lakins Johnathon N JN Weaver Valerie M VM
Cell stem cell 20160721 4
Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate. Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear how these physical cues influence stem cells in culture. We used human embryonic stem cells (hESCs) to examine whether mechanical features of the extracellular microenvironment could differentially modulate mesoderm specification. We found that, on a hydrogel-based co ...[more]